NAME:
JOSEPH SAPONARO, MD, DABIM, FACP, CPI, CCI, CCTI, CCRC, CCRP

TITLE:
PI (Principal Investigator), DSI (Drug Study Institute)
Board Certified Internist, JPMC (Jupiter Preventive Medicine Center)
Expert Medical Witness, ExpertMD
DABIM (Diplomat American Board of Internal Medicine)
FACP (Fellow American College of Physicians)
CPI (Certified Physician Investigator) by the AAPP (American Academy of Pharmaceutical Physicians)
CCTI (Certified Clinical Trial Investigator) by the ACRP (Association of Clinical Research Professionals)
CCI (Certified Clinical Investigator) by the DIA (Drug Information Association)
CCRC (Certified Clinical Research Coordinator) by the ACRP (Association of Clinical Research Professionals)
CCRP (Certified Clinical Research Professional) by SoCRA (Society of Clinical Research Associates)
Founder, CertifiedResearchers.com
IRB Member, Jupiter Medical Center
Clinical Instructor of Pharmacy Practice, Palm Beach Atlantic University

ADDRESS:
1004 South Old Dixie Highway, Suite 201, Jupiter, FL 33458-7200

CONTACT US:
(24/7 phone) 561-575-1212 (fax) 561-745-6664 (Toll Free) 866-575-1212

MEDICAL SCHOOL:
Noreste, Tampico, Mexico

DEGREE:
MD, December 1981

UNDERGRAD:
BS, Pre-Med, Brooklyn College, December 1977

EXTERNSHIPS:
3rd and 4th year medical school externships done from December 1979 through December 1981 at the following institutions:
Baptist Medical Center of New York
Coney Island Hospital
Brooklyn VA Hospital
Kings County Hospital
Brookdale Hospital Medical Center
Methodist Hospital of Brooklyn
Yale-New Haven Medical Center

REFERENCES:
Available upon request

POST MD TRAINING:
Fifth Pathway: Brookdale Hospital Medical Center thru Downstate School of Medicine (8/82-83)

RESIDENCY TRAINING:
PGY-1 General Surgery:New York University Medical Center, Bellevue Hospital, Manhattan VA (7/83-6/84)
PGY-2 General Surgery:St. Vincent's Hospital and Medical Center of New York (7/85-6/86)
PGY-1 Internal Medicine:Jamaica Hospital, NY (7/86-6/87)
PGY-2 Internal Medicine:Jamaica Hospital, NY (7/87-2/88) (lateral move to) The Stamford Hospital, CT (3/88-6/88)
PGY-3 Internal Medicine:The Stamford Hospital, CT (7/88-7/89)
ICU Fellow: The Stamford Hospital, CT (8/89-6/90)

CERTIFIED IN:
Internal Medicine by the American Board of Internal Medicine (ABIM)
Diplomat American Board Internal Medicine (DABIM)
Fellow American College of Physicians (FACP)
Certified Physician Investigator (CPI) by the American Academy of Pharmaceutical Physicians (AAPP)
Certified Clinical Investigator (CCI) by the Drug Information Association (DIA)
Certified Clinical Trials Investigator (CCTI) by the Association of Clinical Research Professionals (ACRP)
Certified Clinical Research Coordinator (CCRC) by the Association of Clinical Research Professionals (ACRP)
Certified Clinical Research Professional (CCRP) by the Society of Clinical Research Associates (SoCRA)

MEMBERSHIP IN PROFESSIONAL SOCIETIES:
BLS (Basic Life Support)
ALS (Advanced Life Support)
Advanced Trauma Life Support
Academy for International Medical Studies
American Academy of Pain Management
The American College of Forensic Examiners Institute of Forensic Science
American Academy of Pharmaceutical Physicians (AAPP)
American Association for Clinical Chemistry (AACC)
American Association of Pharmaceutical Scientists (AAPS)
American College of Clinical Pharmacy (ACCP)
American College of Emergency Physicians 103707
American College of Physicians 026555
American College of Preventive Medicine (ACPM)
American Geriatrics Society
American Medical Association 649-35-82-020-9
American Pharmaceutical Association (APhA)
American Running and Fitness Association
American Society of Bariatric Physicians
American Society of Concierge Physicians (ASCP)
American Society of Internal Medicine
Association of Clinical Research Professionals (ACRP)
Connecticut Society of Internal Medicine
Drug Information Association (DIA)
Florida Medical Association
Florida Society for Preventive Medicine
Florida Thoracic Society
Kings County Medical Society
Lake Placid Sports Medicine Society
Medical Society of the State of New York
National Strength and Conditioning Association
New York Road Runners Club
Palm Beach County Medical Society
Society of Critical Care Medicine 006148

PROFESSIONAL EXPERIENCE:
Jamaica Hospital, NY, ER and Orthopaedics (9/84-6/85)
Optifast Program at Stamford Hospital, CT (2/89-6/90)
Medical Associates of West Palm Beach, FL, Internal Medicine (7/90-2/91)
Center Street Medical, Jupiter, FL, Internal Medicine (2/91-1/92)
Guylaine Lanctot Clinique, Palm Beach, FL, Sclerotherapy (12/91-2/93)
Director Skilled Service, Jupiter Care Center
The Jupiter Preventive Internal Medicine Center, FL (1/92-present)
The Drug Study Institute, Jupiter, FL (1/97-present)

PUBLICATIONS/HONORABLE MENTIONS:

1. Carl J. Pepine, MD, JAMA, 3 December 2003, "A Calcium Antagonist vs a Non-Calcium Antagonist Hypertension Treatment Strategy for Patients with Coronary Artery Disease," The International Verapamil-Trandolapril Study (INVEST): A Randomized Controlled Trial.
2. Jones PH, Davidson MH, Stein EA, et al. Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR Trial). Am J Cardiol 2003; 92:152-160.
3. AMAZE: "Antihypertensive efficacy of adding candesartan cilexetil to lisinopril in comparison to up titration of lisinopril. A multi-center trial using Atacand-Zestril to evaluate the effects on lowering blood pressure."
4. ATGOAL Poster for presentation at EAS (The European Atherosclerosis Society) on 15 January 2004 in Seville, Spain put together with the help of colleagues and fellow ATGOAL investigators: James McKenney, Michael Davidson, Paul Thompson and Harold Bays. DSI was the highest enroller in the ATGOAL Trial (Atorvastatin Goal Achievement Across Risk Levels) comparing Lipitor to its competitors. The poster helps describe the efficacy and safety of atorvastatin initiated at optimal starting doses in achieving LDL-C goals in patients with dyslipidemia.
5. Effects of Exenatide (Exendin-4) on Glycemic Control Over 30 Weeks in Sulfonylurea-Treated Patients With Type 2 Diabetes
6. Honorable mention in April 2006 issue of Florida Trend as a key newcomer involved with Scripps Florida coming to Jupiter, Florida

RESEARCH EXPERIENCE:
Principal Investigator at the Drug Study Institute Within the Jupiter Preventive Internal Medicine Center, a Subsidiary of the Jupiter Preventive Medicine Center, Doing Drug Studies Since 1997
Research IRB, Inc., Chairman (11/00-5/02)
Ethics Committee, Jupiter Medical Center (2/01-pres)
IRB Board Member, Palm Beach Gardens Medical Center (1/03-7/04)
IRB Board Member, Jupiter Medical Center (4/03-pres)
Member Investigator Council, AAPP
Member Publications Committee, AAPP

1997
Smart Study Asthma Research (Serevent, GSK)
Hypertension — Searle

1998
P.O.W.E.R. Trial (HTN) — Hoechst Marion Roussel
INVEST (HTN) — Knoll (honorable mention in publication)
C.O.H.E.R.E. Study (Coreg) — Smith Kline Beecham
Tamiflu — Roche

1999
Community Acquired Pneumonia — Abbott
Geriatric Nutrition Study — Mead Johnson
Cancer Nutrition Study — Mead Johnson
Flu Surveillance — Roche

2000
Blood Draw — Genomics
Hypertension (2/00) — Novartis
Diabetes — Novartis (Starlix)
IBS Registry — Glaxo Wellcome
MICAT — Micardis (HTN) — Boehringer Ingelheim
Genetics Registry — Novartis
Hypertension (5/00) — Novartis
Hypertension (OCTAVE) — Bristol-Myers Squibb
Flu Surveillance — Roche

2001
STRENGTH 1 & 2 (Cholesterol) — Genaissance
Diabetes Type 2 — Amylin
Diabetes Type 2 — Bristol-Myers Squibb
SAPPHIRE (HTN) — Alteon
AMAZE (HTN) — AstraZeneca (honorable mention in publication)
STELLAR (Cholesterol) — AstraZeneca (honorable mention in publication)
Vaccine — Aventis Pasteur
Community Acquired Pneumonia — Ortho McNeil
AT GOAL (Cholesterol) — Pfizer (EAS poster presentation)
LIFT (Osteoporosis) — Organon

2002
STELLAR (Cholesterol) — AstraZeneca (honorable mention in publication)
IRIS (Cholesterol) — AstraZeneca
Cholesterol — BMS
Cholesterol — Genaissance
AT GOAL (Cholesterol) — Pfizer (EAS poster presentation)
AMAZE (HTN) — AstraZeneca (honorable mention in publication)
SAPPHIRE (HTN) — Alteon
NEB-321 (HTN) — Bertek Pharmaceuticals
LIFT (Osteoporosis) — Organon
112 NIDDM — Amylin
113 NIDDM — Amylin
115 NIDDM — Amylin
025-00 NIDDM — Merck
018-00 NIDDM — Merck
CAP (Community Acquired Pneumonia) Levaquin — Advanced Biologics

2003
STELLAR (Cholesterol) — AstraZeneca (honorable mention in publication)
IRIS (Cholesterol) — AstraZeneca
COMETS (Cholesterol) — AstraZeneca
POLARIS (Cholesterol) — AstraZeneca
112 NIDDM — Amylin
113 NIDDM — Amylin
115 NIDDM — Amylin
025-00 NIDDM — Merck
018-00 NIDDM — Merck
BUP 3012 Chronic Pain Hip & Knee — IRD Stamford (Purdue Pharma LP)
HTN ATTACH — AstraZeneca
Glucometer Study — Home Diagnostics

2004
STELLAR (Cholesterol) — AstraZeneca (honorable mention in publication)
STARSHIP (Cholesterol) — AstraZeneca
ATTACH (HTN) — AstraZeneca
BUP 3012 Chronic Pain Hip and Knee — IRD Stamford (Purdue Pharma LP)
BUP 3011 Chronic Pain Hip and Knee Pain in patients on narcotics
BUP 3015 Chronic LBP — IRD Stamford (Purdue Pharma LP)
113 NIDDM Amylin
POLARIS (Cholesterol) — AstraZeneca
Co-Diovan (HTN) Novartis
INCLUSIVE (HTN) BMS and Sanofi-Synthelabo
Pravachol Hepatitis (BMS)
DiZo (Novartis) Zocor + Diovan
Pfizer Lipitor Torcetrapib Protocol #A5091018

2005
STARSHIP (Cholesterol) — AstraZeneca
BUP 3012 Chronic Pain Hip and Knee — IRD Stamford (Purdue Pharma LP)
BUP 3011 Chronic Pain Hip and Knee Pain in patients on narcotics
BUP 3015 Chronic LBP — IRD Stamford (Purdue Pharma LP)
Co-Diovan/DiZo (HTN) Novartis
Pravachol Hepatitis (BMS)
APD356-003 (Obese) — Arena/PPD/Quintiles/RCRC
Altea Narcotic Patch
APD356-004 (Obese) — Arena/PPD/Quintiles/RCRC
Palladone, Narcotic Pill, Purdue Pharma
Rivoglitazone, CS-011-203, (NIDDM) — Sankyo Pharma Development (SPhD)/MedPace/MRLi/Quorum
Dabigatran vs. Coumadin, Protocol #1160.26, Boehringer Ingelheim
BUP 3015 Chronic LBP — IRD Stamford (Purdue Pharma LP)
BUP 3019 Chronic LBP — IRD Stamford (Purdue Pharma LP)
Vax014, Smallpox
LBP, DOV, Bicifadine
Progenics Opioid-Induced Bowel Dysfunction MNTX

2006
Abbott Cholesterol Fenofibric Acid M05-748
Abbott Cholesterol Fenofibric Acid M05-758
Abbott Vicodin CR OA Hip & Knee MO4-697
Altea Therapeutics Chronic Hip and Knee OA Pain Trial
Covalent HTN Darusentan
BMS TZD Diabetes Study Saxagliptin
Daiichi Sankyo Pharma Development/Integrium Benicar HTN
Daiichi Sankyo Pharma Development/Medpace Rivoglitazone NIDDM
Encysive, TBC3711, Resistant HTN
GSK 012 Alvimopan Opioid-Induced Bowel Dysfunction
GSK 014 Alvimopan Opioid-Induced Bowel Dysfunction Extension
GSK/CTMS Constipation Observational Trial
Inc Research/Alpharma Kadian Hip & Knee Pain
Inc Research/Alpharma Kadian Hip & Knee Pain Long-Term Extension
Kos Pharmaceuticals Inc. Niaspan ER + Zocor
LBP, DOV, Bicifadine
Merck/Integrium Lipitor + Zetia
Myogen, Resistant HTN, Darusentan
NIDDM-HDN Novo Nordisk
Pain Therapeutics, Inc., Hip, Knee & LBP, Tamper Resistant Oxycodone
Pain Therapeutics, Inc., Tamper Resistant Oxycodone
Pfizer, PPAR, NIDDM
Pozen/Scirex HI RISK PUD, 303
Pozen/Scirex, PN200, AT RISK PUD 302
Sanofi-Aventis, IDDM, Apidra
Takeda 003 NIDDM
Takeda 004 ICON NIDDM HTN
Takeda 475-009 Cholesterol Lipitor
Takeda 475-010 Cholesterol Lipitor Extension
Takeda 475-020 Cholesterol Zocor
Takeda 475-022 Cholesterol Crestor
Takeda-ICON HTN-NIDDM 536
Takeda SYR-320PI-002 NIDDM
Wyeth Opioid-induced Bowel Dysfunction 3200A3-200-WW

2007
Abbott Laboratories/ICON Crestor + Tricor
Alpharma/Inc Research OA Hip & Knee
Daiichi Sankyo Inc./ICON Benicar-HCT
Forest Research Institute/Integrium Nebivolol HTN
Merck/Integrium EZ Path Trial Lipitor + Zetia
Penwest/i 3 Research Nubain ER OA Hip or knee
Sciele Pharma Inc./Integrium Pravafen
Pfizer/Quintiles Precision Trial; Celebrex
Purdue Pharma LP/PRA International LBP Buprenorphine

2008
Sciele Pharma Inc./Integrium Pravafen
Purdue Pharma LP/PRA International OA Knee Buprenorphine
Daiichi Sankyo Inc./ICON Benicar-HCT
Forest Research Institute/Integrium Nebivolol HTN
Lantus Vs. Byetta/Sanofi-Aventis/Quintiles
Euvolemic Hyponatremia/Lixivaptan/Parexel International
Nebivolol NEB-MD10 HTN/Forest Research Institute/Integrium LLC
Hip & Knee OA/NicOx SA/ Naproxcinod
OA Knee/Neuromed Pharmaceuticals Inc./ PRA International/OROS
Nexium + Naproxen/Pozen/Scirex
CAP/Replidyne Inc. /Inc Research
OBD/OPAL/Sucampo/Covance/Amitiza
Qnexa/Obese/ OB 302/Vivus Inc.
Qnexa/Obese/ OB 303/Vivus Inc.
Roche/Quintiles/CHD Risk
Flu/BioCryst/Covance/Encorium/Peramivir
AMI/Roche/Quintiles
AZOR/Benicar-Norvasc-HCTZ/Daiichi Sankyo/Medpace
HTN DARA/Pharmacopeia/PharmaNet
HTN & CAD Bystolic/Forest Research Institute

2009
NIDDM/JNJ; JNJ-28431754 vs. Amaryl
Resistant HTN Inspra/Great Lakes Drug Development/Novartis/Integrium
PRECISION NSAID Safety/Pfizer/Quintiles
Trilipix/Abbott/ICON/Dyslipidemia
HTN Benicar/Daiichi Sankyo/Integrium
NIDDM Glucagon Receptor Antagonist/Lilly/Parexel
Severe Dyslipidemia Mipomersen/ Genzyme/Medpace

2010
PRECISION NSAID Cardiac Safety/Pfizer/Quintiles
NATURE New Advil/Logical Therapeutics/PRA International
COMET Depression BMS/13 Research

AVAILABILITY:
For Investigational New Drug Trials